Abstract
The experiments were performed on female Wistar rats that received aluminum chloride every day intraperitoneally, 4 mg Al/kg for 3 weeks. In the blood selected morphological factors and delta-aminolevulinic acid dehydratase activity (ALA-D) were investigated. In the kidney and liver ALA-D, delta-aminolevulinic acid synthase (ALA-S), and heme oxygenase activity were also determined. After aluminum chloride administration the most sensitive indicator was an increase of heme oxygenase activity in the liver and a decrease in iron levels in the serum of rats. Aluminum also increased ALA-S activity in the kidney and liver of rats. No changes of ALA-D activity in the liver, the kidney, and the blood were observed. The decreasing of hemoglobin, hematocrit, mean corpuscular hemoglobin mass, and mean corpuscular hemoglobin concentration was noted after 3 weeks of exposure.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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5-Aminolevulinate Synthetase / blood
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5-Aminolevulinate Synthetase / metabolism
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Aluminum Chloride
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Aluminum Compounds / administration & dosage
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Aluminum Compounds / toxicity*
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Analysis of Variance
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Animals
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Astringents / administration & dosage
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Astringents / toxicity
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Chlorides / administration & dosage
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Chlorides / toxicity*
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Female
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Hematocrit
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Hematopoiesis / drug effects*
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Heme Oxygenase (Decyclizing) / blood
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Heme Oxygenase (Decyclizing) / metabolism
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Hemoglobins / metabolism
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Injections, Intraperitoneal
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Iron / blood
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Kidney / drug effects*
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Kidney / enzymology
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Liver / drug effects*
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Liver / enzymology
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Porphobilinogen Synthase / blood
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Porphobilinogen Synthase / metabolism
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Rats
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Rats, Wistar
Substances
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Aluminum Compounds
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Astringents
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Chlorides
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Hemoglobins
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Aluminum Chloride
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Iron
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Heme Oxygenase (Decyclizing)
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5-Aminolevulinate Synthetase
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Porphobilinogen Synthase